Walk away splits take time. I try to suggest using swarm cells or buy queens, so the time will be reduced between split and having a laying queen again.
However, if that isn't possible, or not desirable, then yeah, it can be done. I use all medium equipment for everything, it saves me problems and weight. I have done splits both ways.
I have had better luck with a 5 frame nuc, and stacking another five frame box above the first once they get going. THEN when they are up and running in both boxes, i move both five frame nucs down into a ten frame hive body and give them a new box above.
For some reason, they seem to grow faster in the nuc then when I just start them out in the ten frame hive body.
When you do a walk away split, you have to make SURE they have plenty of bees and brood. Bees will be dying off while they wait for a laying queen, and you don't want to end up with low numbers of bees when the laying queen arrives.
Scott